The point-and-click adventure game "A Vampyre Story" tells the tale of the beautiful, gifted opera singer Mona De Lafitte, whose life is brought to an abrupt end by a vampire baron named Shrowdy Von Kiefer. Henceforth, she is doomed to a miserable existence as a creature of the night in Von Kiefer's gloomy castle in Draxsylvania. Confronted with her seemingly hopeless fate she decides to run away and try to fulfill her dream of singing at the Paris Opera. Accompanied by her mischievous bat Froderick, Mona must face a number of challenges in her odyssey and learn not only to accept her vampire nature, but also to use the abilities she has acquired to her advantage.

For no apparent reason, ordinary people are killing total strangers. Although there are no direct links between the murders, they all show the same ritual patterns. Lucas Kane becomes one of these murderers, and haunted by strange visions he must try to keep one step ahead of the police to discover what is happening to him.